Hydroxyamine hydrochloride → 3-(Pyridin-4-yl)-1,2-oxazol-5-amine

HRID 491531노트

반응식

HRID 491531 반응식
O=[C:2]([C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)[CH2:3][C:4]#[N:5].Cl.[NH2:13][OH:14]>C(O)C>[N:9]1[CH:10]=[CH:11][C:6]([C:2]2[CH:3]=[C:4]([NH2:5])[O:14][N:13]=2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 157315353-Oxo-3-(pyridin-4-yl)propanenitrile

생성물 1

HCID 127178543-(Pyridin-4-yl)-1,2-oxazol-5-amine수율 68.9%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

To 3-oxo-3-pyridin-4-yl-propionitrile (2.0 g, 13.7 mmol) in 20 mL of ethanol was added hydroxylamine hydrochloride (0.75 g, 10.8 mmol) and the resulting solution was heated at 70° C. overnight. The resulting white precipitate was collected and the solution was concentrated and dried in vacuum to afford the title compound (1.2 g, 54%) as a yellow solid. FIA MS: MH+162.2, M−160.0.

후처리

  1. customThe resulting white precipitate was collected
  2. concentrationthe solution was concentrated
  3. customdried in vacuum

출처 및 근거

ORD 기록
ord-17cb97e1e8d6499e96b5cd3e3bd0b106
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531556B2

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