Benzyl Isothiocyanate → 4-Benzyl-2-(4-methoxybenzyl)-[1,2,4]thiadiazolidine-3,5-dione

HRID 491697

반응식

HRID 491697 반응식
[CH2:1]([N:8]=[C:9]=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:22]=[CH:21][C:16]([CH2:17][N:18]=[C:19]=[O:20])=[CH:15][CH:14]=1.C([O:25]CC)C>>[CH2:1]([N:8]1[C:9](=[O:25])[S:10][N:18]([CH2:17][C:16]2[CH:21]=[CH:22][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)[C:19]1=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 2346Benzyl IsothiocyanateHCID 3283Diethyl EtherHCID 187910Isocyanic acid, p-methoxybenzyl-

생성물 1

HCID 116023364-Benzyl-2-(4-methoxybenzyl)-[1,2,4]thiadiazolidine-3,5-dione

실험 절차

Reagents: Benzylisothiocyanate (6.5 mmol, 0.85 mL), p-metoxybenzyl-isocyanate (6.5 mmol, 0.92 mL) and SO2Cl2 (6.5 mmol, 0.52 mL) in diethyl ether (25 mL). Isolation: solvent evaporation. Purification: silica gel column chromatography (AcOEt/hexane, 1:4).

후처리

  1. customIsolation: solvent evaporation
  2. customPurification

출처 및 근거

ORD 기록
ord-4e52b385adcd42919837a9ef2abb0606
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531561B2

연결된 노트

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