Acetone → 4-(5-Fluoro-2-methylphenyl)-3-buten-2-one

HRID 49189노트

반응식

HRID 49189 반응식
[OH-].[Na+].O.[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:12]=1)[CH:10]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:10]=[CH:14][C:15](=[O:16])[CH3:17])[CH:12]=1

참가 물질

5

반응물 4

HCID 180Acetone2회HCID 962WaterHCID 14798Sodium HydroxideHCID 27590125-Fluoro-2-methylbenzaldehyde

생성물 1

HCID 540396424-(5-Fluoro-2-methylphenyl)-3-buten-2-one

실험 절차

A mixture of acetone (80 ml), sodium hydroxide (3.7 g) and water (100 ml) was treated at room temperature dropwise with a solution of 5-fluoro-2-methylbenzaldehyde (11.5 g) in acetone (30 ml) and stirred at the same temperature for 1 hour. Acetone was distilled off under reduced pressure, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and concentrated under reduced pressure to obtain 4-(5-fluoro-2-methylphenyl)-3-buten-2-one (13.4 g).

후처리

  1. distillationAcetone was distilled off under reduced pressure
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed successively with water and saturated brine
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-79e6aaa0f0ab48a2bfc1ef78b562a897
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706732B1

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