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Chloroform → 3,3-Dichloropiperidin-2-one

HRID 491936
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HRID 491936 반응식
[C:1]1(=[O:7])[NH:6][CH2:5][CH2:4][CH2:3]C1.P(Cl)(Cl)(Cl)(Cl)Cl.[CH:14]([Cl:17])(Cl)[Cl:15]>>[Cl:15][C:14]1([Cl:17])[CH2:3][CH2:4][CH2:5][NH:6][C:1]1=[O:7]
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참가 물질

4

반응물 3

HCID 6212ChloroformHCID 126652-PiperidoneHCID 24819Phosphorus pentachloride

생성물 1

HCID 3225653,3-Dichloropiperidin-2-one

실험 절차

Part A. To valerolactam (5.6 g, 55 mmol) in CHCl3 was added PCl5 (34.6 g, 166 mmol) and the reaction was heated to reflux 24 h. The reaction was cooled, quenched with H2O, extracted with CHCl3 and dried (MgSO4) to afford crude 3,3-dichloro-2-piperidinone.

후처리

  1. temperaturethe reaction was heated
  2. temperatureto reflux 24 h
  3. temperatureThe reaction was cooled
  4. customquenched with H2O
  5. extractionextracted with CHCl3
  6. dry with materialdried (MgSO4)

출처 및 근거

ORD 기록
ord-a960fbde0eb244ba93763997a714a031
출처 데이터셋
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07531535B2

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