Acetone → 4-(2,5-Difluorophenyl)but-3-en-2-one

HRID 49203

반응식

HRID 49203 반응식
[OH-].[Na+].O.[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=[CH:14][C:15](=[O:16])[CH3:17]

참가 물질

5

반응물 4

HCID 180Acetone2회HCID 962WaterHCID 14798Sodium HydroxideHCID 1376632,5-Difluorobenzaldehyde

생성물 1

HCID 14817594-(2,5-Difluorophenyl)but-3-en-2-one

실험 절차

A mixture of acetone (45 ml), sodium hydroxide (3.1 g) and water (230 ml) was combined at room temperature with a solution of 2,5-difluorobenzaldehyde (10.0 g) in acetone (10 ml) and stirred at the same temperature for 30 minutes. Acetone was distilled off under reduced pressure and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and concentrated under reduced pressure to obtain 4-(2,5-difluorophenyl)-3-buten-2-one (13.8 g).

후처리

  1. distillationAcetone was distilled off under reduced pressure
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed successively with water and saturated brine
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8199b19ea870431cb22c15b0a484ca72
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706732B1

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