Acetone → 4-(2,5-Difluorophenyl)but-3-en-2-one
반응식
[OH-].[Na+].O.[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=1[CH:7]=[CH:14][C:15](=[O:16])[CH3:17]참가 물질
5
실험 절차
A mixture of acetone (45 ml), sodium hydroxide (3.1 g) and water (230 ml) was combined at room temperature with a solution of 2,5-difluorobenzaldehyde (10.0 g) in acetone (10 ml) and stirred at the same temperature for 30 minutes. Acetone was distilled off under reduced pressure and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine and concentrated under reduced pressure to obtain 4-(2,5-difluorophenyl)-3-buten-2-one (13.8 g).
후처리
- distillationAcetone was distilled off under reduced pressure
- extractionextracted with ethyl acetate
- washThe organic layer was washed successively with water and saturated brine
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8199b19ea870431cb22c15b0a484ca72
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06706732B1
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