Ammonium Acetate → 1-Amino-5-(2,5-difluorophenyl)cyclohexan-3-one

HRID 49205노트

반응식

HRID 49205 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][C:13](=O)[CH2:12][C:11](=[O:16])[CH2:10]1.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:13]1[CH2:14][CH:9]([C:3]2[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:10][C:11](=[O:16])[CH2:12]1

참가 물질

4

반응물 2

HCID 517165Ammonium AcetateHCID 178239175-(2,5-Difluorophenyl)cyclohexane-1,3-dione

생성물 1

HCID 178239181-Amino-5-(2,5-difluorophenyl)cyclohexan-3-one수율 92.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 5-(2,5-difluorophenyl)cyclohexane-1,3-dione (4.0 g) and ammonium acetate (4.1 g) in ethanol (60 ml) was heated under reflux for 12 hours. The reaction mixture was concentrated under reduced pressure, and the residue was washed with water and dried to obtain 1-amino-5-(2,5-difluorophenyl)cyclohexan-3-one (3.7 g).

후처리

  1. temperatureunder reflux for 12 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washthe residue was washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-127ad5525e15414fa8391ce0006812bd
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706732B1

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