Hydrochloric Acid → HCID 178428136, 화합물

HRID 49207노트

반응식

HRID 49207 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:18][C:17]2[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=2[C:11](=O)[CH2:10]1.[C:21]([NH:24][NH2:25])([NH2:23])=[NH:22].[ClH:26].Cl.O>C(O)C>[ClH:26].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:18][C:17]2[N:16]=[CH:15][CH:14]=[C:13]([CH3:19])[C:12]=2[C:11](=[N:25][NH:24][C:21]([NH2:23])=[NH:22])[CH2:10]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 110869317-(2,5-Difluorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-oneHCID 178418668HCID 178418668, 화합물

생성물 1

HCID 178428136HCID 178428136, 화합물수율 99.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 7-(2,5-difluorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (1.2 g) and aminoguanidine hydrochloride (0.58 g) in ethanol (30 ml) was combined with concentrated hydrochloric acid (1.1 ml) and water (1.1 ml), and the mixture was heated under reflux for 14 hours. The solvent was distilled off under reduced pressure, and the resultant crystal was recrystallized from ethanol to obtain 7-(2,5-difluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound K) (1.6 g) as a colorless crystal.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 14 hours
  3. distillationThe solvent was distilled off under reduced pressure
  4. customthe resultant crystal was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-4f1d164094b047a693bf9993ac9e2f7b
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706732B1

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