[Na].CO.[ClH:4].[NH2:5][C:6]([NH2:8])=[NH:7].[Cl:9][C:10]([C:12]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[N:14]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[CH:25][CH:24]=2)[CH:13]=1)=[O:11]>COCCOC>[ClH:9].[ClH:4].[NH:7]([C:10]([C:12]1[C:20]2[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=2)[N:14]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[CH:25][CH:24]=2)[CH:13]=1)=[O:11])[C:6]([NH2:8])=[NH:5]0.87 g (38 mmol) of sodium is added at a temperature in the region of 22° C. under an argon atmosphere to 60 cm3 of methanol. After complete dissolution, 3.6 g (37.5 mmol) of guanidine hydrochloride are added. After stirring at a temperature in the region of 22° C. for 1 hour, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give a residue which is suspended in 60 cm3 of 1,2-dimethoxyethane. 2.4 g (7.13 mmol) of 3-chlorocarbonyl-6-methoxy-1-(quinol-4-yl)-1H-indole are subsequently added at a temperature in the region of 22° C. under an argon atmosphere. After stirring at reflux for 18 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give a residue which is triturated in 100 cm3 of water. The suspension is filtered and dried to give a beige-coloured powder which is purified by silica gel chromatography [eluent: dichloromethane/methanol (85/15 by volume)]. After concentrating the fractions under reduced pressure (2.7 kPa), 1.7 g of a beige-coloured foam are obtained, which foam is triturated in 60 cm3 of N hydrochloric acid to provide, after filtration, 1.86 g of 3-guanidinocarbonyl-6-methoxy-1-(quinol-4-yl)-1H-indole dihydrochloride in the form of yellow crystals melting at a temperature of greater than 260° C. Mass spectrum (EI): m/e 359 (M+·), m/e 301. IR spectrum (KBr): 3356, 2587, 1694, 1630, 1595, 1542, 1495, 1441, 1261, 1232, 1192, 823 and 763 cm−1.
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