2-(Thiophen-2-ylmethyl)isoindoline-1,3-dione → HCID 4616003, 화합물

HRID 492227노트

반응식

HRID 492227 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]1=[O:17].[BH4-].[Na+]>CO>[OH:16][CH:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:17])[N:7]1[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 33541542-(Thiophen-2-ylmethyl)isoindoline-1,3-dioneHCID 4311764Sodium borohydride

생성물 1

HCID 4616003HCID 4616003, 화합물수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

To a suspension of 11 (700 mg, 2.88 mmol) in methanol (15 mL) at 0° C. was added sodium borohydride (164 mg, 4.32 mmol) and the resulting reaction mixture was allowed to stir at 0° C. for 2 hours. The reaction mixture was concentrated in vacuo to remove methanol and the residue was taken up in ethyl acetate and poured onto 1N HCl and extracted with ethyl acetate (3×30 mL). The combined ethyl acetate extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to provide 612 mg of 12 as a yellow solid (706 mg theoretical, 87% yield).

후처리

  1. customthe resulting reaction mixture
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customto remove methanol
  4. additionpoured onto 1N HCl
  5. extractionextracted with ethyl acetate (3×30 mL)
  6. dry with materialThe combined ethyl acetate extracts were dried over anhydrous sodium sulfate
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e04d2ed933b44138ae1246d4b06afbb9
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531671B2

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