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Hydrochloric Acid → (4-Propylphenyl)methanol

HRID 493035
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HRID 493035 반응식
O1CCCC1.C[O:7][C:8](=O)[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH3:17])=[CH:11][CH:10]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl>O.CO>[CH2:15]([C:12]1[CH:11]=[CH:10][C:9]([CH2:8][OH:7])=[CH:14][CH:13]=1)[CH2:16][CH3:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8028Tetrahydrofuran2회HCID 12861010Methyl 4-propylbenzoateHCID 21226445Aluminium lithium hydride2회

생성물 1

HCID 2760472(4-Propylphenyl)methanol수율 98.5%

시약·촉매·용매 2

HCID 887Methanol
용매
HCID 962Water용매

실험 절차

Dried tetrahydrofuran (50 ml) in which 10.4 g (58.4 mmol) of 4-n-propylbenzoic acid methyl ester synthesized in step (i) was dissolved was dropwise added to 50 ml of dried tetrahydrofuran containing suspension of lithium aluminium hydride (1.54 g: 40.5 mmol) at a temperature of not more than 10° C. with cooling with ice, and reaction was carried out at a room temperature overnight. After the completion of the reaction, an excess amount of lithium aluminium hydride was reacted with methanol with cooling with ice. Next water and an aqueous solution of hydrochloric acid were successively added to the reaction mixture, and the resultant was extracted with hexane. After the hexane phase was washed with water, hexane was removed from the hexane phase to give 8.63 g (57.5 mmol) of 4-n-propylbenzyl alcohol.

후처리

  1. temperaturewith cooling with ice, and reaction
  2. customAfter the completion of the reaction
  3. temperaturewith cooling with ice
  4. extractionthe resultant was extracted with hexane
  5. washAfter the hexane phase was washed with water, hexane
  6. customwas removed from the hexane phase

출처 및 근거

ORD 기록
ord-a6779d30ec104bc38523bca87f1e820f
출처 데이터셋
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07534547B2

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