Thionyl Chloride → 1-(Chloromethyl)-4-propylbenzene

HRID 493036노트

반응식

HRID 493036 반응식
[CH2:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]O)=[CH:6][CH:5]=1)[CH2:2][CH3:3].S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[CH2:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][Cl:14])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 2760472(4-Propylphenyl)methanol

생성물 1

HCID 122531731-(Chloromethyl)-4-propylbenzene수율 97%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

In 50 ml of chloroform was dissolved 8.63 g (57.5 mmol) of 4-n-propylbenzyl alcohol synthesized in the step (ii), and 8.10 g (68.1 mmol) of thionyl chloride was added to the mixture. The mixture was subjected to reaction at a room temperature for 24 hours. After the completion of the reaction, the chloroform phase was washed successively with an aqueous solution of sodium hydrogencarbonate and water. Chloroform was removed from the chloroform phase to give 9.40 g (55.8 mmol) of 4-n-propylbenzylchloride.

후처리

  1. additionwas added to the mixture
  2. customThe mixture was subjected to reaction at a room temperature for 24 hours
  3. customAfter the completion of the reaction
  4. washthe chloroform phase was washed successively with an aqueous solution of sodium hydrogencarbonate and water
  5. customChloroform was removed from the chloroform phase

출처 및 근거

ORD 기록
ord-efb9c43b1460418aabf8d823c1a5a25b
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534547B2

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