Phosphorus oxychloride → 2,4-dimethoxy-5-methylbenzaldehyde

HRID 493207

반응식

HRID 493207 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH3:11].O=P(Cl)(Cl)Cl.CN(C1C=CC=CC=1)[CH:19]=[O:20]>>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[C:4]([CH3:11])=[CH:5][C:6]=1[CH:19]=[O:20]

참가 물질

4

반응물 3

HCID 24813Phosphorus oxychlorideHCID 66737N-MethylformanilideHCID 96403Benzene, 2,4-dimethoxy-1-methyl-

생성물 1

HCID 2516922,4-dimethoxy-5-methylbenzaldehyde

실험 절차

To a solution of 2,4-dimethoxytoluene (5.50 g, 36.1 mmol) in 55 mL of N-methyl-N-phenyl-formamide was added at 0° C. POCl3 (10.9 mL, 3 eq.), and the mixture was heated for 60 Min. to 80° C. After cooling, the reaction mixture was poured onto crashed ice, the precipitate filtered and washed twice with water/MeOH=8/2 to leave after drying 5.40 g of the title product as light yellow crystals.

후처리

  1. customto 80° C
  2. temperatureAfter cooling
  3. additionthe reaction mixture was poured
  4. filtrationthe precipitate filtered
  5. washwashed twice with water/MeOH=8/2
  6. customto leave
  7. dry with materialafter drying 5.40 g of the title product as light yellow crystals

출처 및 근거

ORD 기록
ord-062f9228e51648be980699e9b000c221
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534788B2

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