2-Methoxy-4-Methylphenol → 2-(2-Methoxy-4-methylphenoxy)ethyl 3-(1-piperazinyl)-2-pyrazinyl ether

HRID 493287

반응식

HRID 493287 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:4]=1[OH:10].C(OC([N:18]1[CH2:23][CH2:22][N:21]([C:24]2[C:25]([O:30][CH2:31][CH2:32]O)=[N:26][CH:27]=[CH:28][N:29]=2)[CH2:20][CH2:19]1)=O)(C)(C)C>>[N:21]1([C:24]2[C:25]([O:30][CH2:31][CH2:32][O:10][C:4]3[CH:5]=[CH:6][C:7]([CH3:9])=[CH:8][C:3]=3[O:2][CH3:1])=[N:26][CH:27]=[CH:28][N:29]=2)[CH2:22][CH2:23][NH:18][CH2:19][CH2:20]1

참가 물질

3

반응물 2

HCID 71442-Methoxy-4-MethylphenolHCID 114160742-[3-(4-Tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol

생성물 1

HCID 220363432-(2-Methoxy-4-methylphenoxy)ethyl 3-(1-piperazinyl)-2-pyrazinyl ether

실험 절차

The title compound was prepared starting from 2-methoxy-4-methylphenol (162 mg, 1.25 mmol) and 2-[3-(4-tert-butoxycarbonyl-1-piperazinyl)-2-pyrazinyloxy]ethanol (1.00 mmol, prepared in Example 52, Step 2) to give 233 mg (67%) of a yellow solid. HRMS m/z calcd for C18H24N4O3 (M)+ 344.1848, found 344.1839.

출처 및 근거

ORD 기록
ord-ba4b5cdc9ca14f9ca4e98baaa909f7ae
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534794B2

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