Carbon Dioxide → 2-(1,3-Benzodioxol-4-yloxy)ethanol

HRID 493335

반응식

HRID 493335 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([OH:10])[C:4]=2[O:3][CH2:2]1.C1(=O)O[CH2:14][CH2:13][O:12]1.C([O-])([O-])=O.[K+].[K+].C(=O)=O>CN(C=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([O:10][CH2:14][CH2:13][OH:12])[C:4]=2[O:3][CH2:2]1

참가 물질

6

반응물 4

HCID 280Carbon DioxideHCID 7303Ethylene carbonateHCID 11430Potassium CarbonateHCID 5867271,3-Benzodioxol-4-ol

생성물 1

HCID 220365462-(1,3-Benzodioxol-4-yloxy)ethanol수율 65%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
150 °C

실험 절차

A mixture of 1,3-benzodioxol-4-ol* (0.74 g, 5:36 mmol), ethylene carbonate (0.47 g, 5.3 mmol) and K2CO3 (0.67 g, 4.8 mmol) in DMF (30 mL) was heated at 150° C. After the evolution of carbon dioxide had ceased (1 h), the reaction mixture was filtered and concentrated. The crude product was purified by chromatography on silica gel using petroleum ether/EtOAc (70:30) as eluent to give 0.64 g (65%) of the title product as an oil which spontaneously crystallized to a white solid: mp 56-57° C. Anal. (C9H10O4) C, H.

후처리

  1. custom(1 h)
  2. filtrationthe reaction mixture was filtered
  3. concentrationconcentrated
  4. customThe crude product was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-644ca6a266d1471d8d5502410cef873a
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534794B2

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