Hydrochloric Acid → Methyl 2-hydroxy-3-phenylpropanoate

HRID 493485노트

반응식

HRID 493485 반응식
Cl.[OH:2][CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([OH:6])=[O:5].[C:14]([O-])(O)=O.[Na+]>CO>[CH3:14][O:5][C:4](=[O:6])[CH:3]([OH:2])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3848(+-)-3-Phenyllactic acidHCID 516892Sodium Bicarbonate

생성물 1

HCID 518800Methyl 2-hydroxy-3-phenylpropanoate수율 90%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Hydrogen chloride was bubbled for 15 minutes into a solution of 2-hydroxy-3-phenyl-propionic acid (10.0 g, 60 mmol) in 100 mL of methanol at room temperature. The vessel was sealed and then stirred overnight at room temperature. The reaction was made basic by the addition of 5% NaHCO3 and then concentrated under reduced pressure to remove the methanol. The residue was diluted with water and extracted with ethyl acetate. The organic layer was extracted with saturated NaCl, dried (MgSO4) and the solvent removed under reduced pressure to give 2-hydroxy-3-phenyl-propionic acid methyl ester (9.7 g, 90%) as a yellow oil, MS m/z 180 [M]+. Elemental Analysis for C10H12O3. Calc'd: C, 66.65; H, 6.71; N, 0.00. Found: C, 66.52; H, 6.86; N, 0.29

후처리

  1. customThe vessel was sealed
  2. concentrationconcentrated under reduced pressure
  3. customto remove the methanol
  4. additionThe residue was diluted with water
  5. extractionextracted with ethyl acetate
  6. extractionThe organic layer was extracted with saturated NaCl
  7. dry with materialdried (MgSO4)
  8. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-6ea0a7a602254a33aa7b2718c017dde1
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534894B2

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