Hydrochloric Acid → 7-Piperidin-4-yl-7,9-dihydro-8H-purin-8-one hydrochloride

HRID 493591노트

반응식

HRID 493591 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[N:18][CH:19]=[N:20][CH:21]=3)[NH:16][C:15]2=[O:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:24]>O1CCOCC1>[ClH:24].[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[N:18][CH:19]=[N:20][CH:21]=3)[NH:16][C:15]2=[O:23])[CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 222932617-(1-benzylpiperidin-4-yl)-7,9-dihydro-8H-purin-8-one

생성물 1

HCID 222931977-Piperidin-4-yl-7,9-dihydro-8H-purin-8-one hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 7-(1-benzylpiperidin-4-yl)-7,9-dihydro-8H-purin-8-one (1.2 g, 3.7 mmol) in 4N hydrogen chloride in dioxane (50 mL), was stirred vigorously at room temperature for 3 h. The reaction was concentrated in vacuo to give the title compound as a white solid. MS 220 (M+1)

후처리

  1. concentrationThe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ab38e3a8080f46829d8b05f9d428820b
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534784B2

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