Triethylamine → 4-(Bis(4-chlorophenyl)methyl)piperazin-2-one

HRID 494052

반응식

HRID 494052 반응식
Cl[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][CH:4]=1.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][C:18]1=[O:23].C(N(CC)CC)C>CC#N>[Cl:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[N:20]2[CH2:21][CH2:22][NH:17][C:18](=[O:23])[CH2:19]2)=[CH:4][CH:5]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 130784,4'-Dichlorobenzhydryl chlorideHCID 231360Piperazin-2-one

생성물 1

HCID 689317794-(Bis(4-chlorophenyl)methyl)piperazin-2-one수율 83.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of chlorobis(4-chlorophenyl)methane (407 mg, 1.5 mmol) in MeCN was added piperazin-2-one (601 mg, 6.0 mmol) followed by triethylamine (626 μl, 4.5 mmol) and the resulting mixture was refluxed overnight. After cooling to rt, the solvent was evaporated to dryness and the residue was submitted to column chromatography (SiO2, DCM to DCM/MeOH=100:5) to give 4-(bis(4-chlorophenyl)methyl)piperazin-2-one (420 mg) as a white solid.

후처리

  1. temperaturethe resulting mixture was refluxed overnight
  2. customthe solvent was evaporated to dryness

출처 및 근거

ORD 기록
ord-27f77bb0ef1241de99bd80c85f018621
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538114B2

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