Sodium Hydroxide → 2-Methyl-6-phenylpyridine-3-carboxylic acid
반응식
[CH3:1][C:2]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]참가 물질
4
실험 절차
Ethyl 2-methyl-6-phenylnicotinate (D18) (284 mg, 1.2 mmol) was treated with aq. 2M NaOH in ethanol at reflux giving the title compound as an off white solid (108 mg). MS (AP): MH+ 214, M-H+ 212.
후처리
- temperatureat reflux
출처 및 근거
- ORD 기록
- ord-004ffcc5f42541bea0055c308d06ccea
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07538121B2
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