7-Aminoquinoline → 6-Chloro-N-quinolin-7-yl-nicotinamide

HRID 494192

반응식

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][N:14]=1>>[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH:1][C:2]2[CH:11]=[C:10]3[C:5]([CH:6]=[CH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)=[O:18])=[CH:15][N:14]=1

참가 물질

반응물 2

HCID 113777-Aminoquinoline

HCID 792226-Chloronicotinic acid

생성물 1

HCID 445789876-Chloro-N-quinolin-7-yl-nicotinamide

실험 절차

Using the procedure outlined in Example 45, the title compound was prepared from 7-aminoquinoline (D55) (213 mg, 1.48 mmol) and 6-chloronicotinic acid (279 mg, 1.77 mmol) as a cream solid (405 mg). 1H NMR (250 MHz, CDCl3) δ (ppm): 8.94 (m, 2H), 8.24 (m, 2H), 8.16 (d, 1H), 8.14 (br.s, 1H), 8.01 (dd, 1H), 7.87 (d, 1H), 7.51 (d, 1H), 7.39 (dd, 1H).

출처 및 근거

ORD 기록: ord-727e4c33b2344710ad301c95ebdd7540
출처 데이터셋: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07538121B2

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