Diethyl Ether → 2,6-Dichloro-4-cyanobenzenediazonium tetrafluoroborate

HRID 494371

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HRID 494371 반응식
[NH2:1][C:2]1[C:9]([Cl:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[Cl:11].[F:12][B-:13]([F:16])([F:15])[F:14].[H+].[N:18](OCCC(C)C)=O.C(OCC)C>C(#N)C>[F:12][B-:13]([F:16])([F:15])[F:14].[Cl:11][C:3]1[CH:4]=[C:5]([C:6]#[N:7])[CH:8]=[C:9]([Cl:10])[C:2]=1[N+:1]#[N:18]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 8053Isoamyl NitriteHCID 28118Tetrafluoroboric acidHCID 5227064-Amino-3,5-dichlorobenzonitrile

생성물 1

HCID 866096552,6-Dichloro-4-cyanobenzenediazonium tetrafluoroborate수율 62.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
0 °C

실험 절차

To a solution of 4-amino-3,5-dichlorobenzonitrile (2.00 g, 10.63 mmol) in acetonitrile (12 ml) was added dropwise tetrafluoroboric acid (2.80 ml, 21.27 mmol). After stirring for 10 min, isoamyl nitrite (1.50 ml, 10.63 mmol) was added and the reaction mixture was cooled to 0° C. After a further 10 min, diethyl ether (50 ml) was added and the resulting precipitate was collected by filtration and dried to give the titled compound (1.9 g).

후처리

  1. waitAfter a further 10 min
  2. filtrationthe resulting precipitate was collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-642f2c82542c4638be26f180b45fce07
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538134B2

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