Hydrochloric Acid → 4-hydroxy-1,1-dimethyl-2(1H)-naphthalenone
반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH3:13])([CH3:12])[C:4](=[O:14])[C:3]=1C(OCC)=O.Cl>O1CCOCC1.C(OCC)(=O)C.O>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH3:12])([CH3:13])[C:4](=[O:14])[CH:3]=1참가 물질
6
반응 조건
- 온도
- 25 °C
실험 절차
A solution of the product of Example 9E (2.25 g, 8.65 mmol) in dioxane (50 mL) was treated with 1 N HCl solution (60 mL) and the mixture was stirred at reflux for 6 hours, cooled to 25° C., diluted with ethyl acetate and water. The organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4), filtered and concentrated in vacuo. The residue was triturated with ether and filtered.
후처리
- temperatureat reflux for 6 hours
- washThe organic layer was washed with water (2×) and saturated sodium chloride solution (1×), dried(Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe residue was triturated with ether
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-e132b16ef53f422793d779137ae29935
- 출처 데이터셋
- uspto-grants-2009_05
- 특허 번호
- US07538105B2
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