Sodium Hydroxide → Sodium (4R)-2-[7-(acetylamino)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-1-olate

HRID 494583노트

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HRID 494583 반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C@@:5]([CH3:17])([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:18])[C:3]=1[C:19]1[NH:24][C:23]2[CH:25]=[CH:26][C:27]([NH:29][C:30](=[O:32])[CH3:31])=[CH:28][C:22]=2[S:21](=[O:34])(=[O:33])[N:20]=1.[OH-].[Na+:36]>O>[C:30]([NH:29][C:27]1[CH:26]=[CH:25][C:23]2[NH:24][C:19]([C:3]3[C:4](=[O:18])[C@:5]([CH3:17])([CH2:12][CH2:13][CH:14]([CH3:15])[CH3:16])[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:2]=3[O-:1])=[N:20][S:21](=[O:33])(=[O:34])[C:22]=2[CH:28]=1)(=[O:32])[CH3:31].[Na+:36]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 135409606N-{3-[(4R)-1-hydroxy-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}acetamide

생성물 1

HCID 86598022Sodium (4R)-2-[7-(acetylamino)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-1-olate수율 993%

시약·촉매·용매 1

HCID 962Water용매

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온도
25 °C

실험 절차

A suspension of the product of Example 44A (0.046 g) in water (1 mL) was treated with 0.997N sodium hydroxide solution (0.090 mL, 0.090 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.45 g, 99%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.45 (m, 1H) 0.69 (m, 6H) 0.80 (m, 1H) 1.27 (m, 1H) 1.37 (m, 3H) 1.72 (m, 1H) 2.06 (m, 3H) 2.15 (m, 1H) 7.23 (m, 1H) 7.32 (m, 1H) 7.46 (m, 2H) 7.65 (m, 1H) 8.03 (m, 2H) 10.13 (m, 1H) 15.44 (m, 1H). MS (ESI−) m/z 480 (M−H)−.

출처 및 근거

ORD 기록
ord-844f57e7882d4149ab99641317f04fd4
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538105B2

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