Tetrahydrofuran → 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide L-(+)-tartrate

HRID 495010노트

반응식

HRID 495010 반응식
[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:35])([CH3:34])[O:10]2)=[CH:5][CH:4]=1.O1CCCC1.[C:42]([OH:51])(=[O:50])[C@@H:43]([C@H:45]([C:47]([OH:49])=[O:48])[OH:46])[OH:44]>C(OCC)C>[C:47]([C@@H:45]([C@H:43]([C:42]([OH:51])=[O:50])[OH:44])[OH:46])([OH:49])=[O:48].[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:34])([CH3:35])[O:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 8028Tetrahydrofuran2회HCID 444305L-Tartaric acidHCID 11677552E-2110 free base

생성물 1

HCID 866016071-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide L-(+)-tartrate수율 84.2%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (100 mg) was dissolved in a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml). Thereafter, a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml) containing L-(+)-tartaric acid (31 mg) was added to the reaction solution at room temperature. The deposited solid was collected by filtration, and the obtained product was then washed with diethyl ether, so as to obtain the subject compound (110 mg).

후처리

  1. additionwas added to the reaction solution at room temperature
  2. filtrationThe deposited solid was collected by filtration
  3. washthe obtained product was then washed with diethyl ether

출처 및 근거

ORD 기록
ord-6da6a0d92e6849b8bdd44d6806ab5369
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07538123B2

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