Sodium Hydroxide → Pentafluorobenzenesulfonamide

HRID 495328

반응식

HRID 495328 반응식
[Cl-].[NH4+:2].[F:3][C:4]1[C:9]([S:10](Cl)(=[O:12])=[O:11])=[C:8]([F:14])[C:7]([F:15])=[C:6]([F:16])[C:5]=1[F:17].[OH-].[Na+]>CC(C)=O>[F:3][C:4]1[C:9]([S:10]([NH2:2])(=[O:12])=[O:11])=[C:8]([F:14])[C:7]([F:15])=[C:6]([F:16])[C:5]=1[F:17]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 700262,3,4,5,6-Pentafluorobenzenesulfonyl chloride

생성물 1

HCID 2063927Pentafluorobenzenesulfonamide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To an aqueous solution of ammonium chloride was added dropwise an acetone solution of pentafluorobenzenesulfonyl chloride at room temperature. During addition, pH was adjusted to 7 by an aqueous sodium hydroxide solution. Precipitated product was filtered and recrystallized from toluene to give pentafluorobenzenesulfonamide. The structure was confirmed by 1H-NMR, 19F-NMR and IR.

후처리

  1. additionDuring addition, pH
  2. filtrationPrecipitated product was filtered
  3. customrecrystallized from toluene

출처 및 근거

ORD 기록
ord-f7708f43148745cca8ced0dff432cb95
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939646B2

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