HCID 22326644, 화합물 → 5-Quinolinol, 6-fluoro-2-methyl-

HRID 495440노트

반응식

HRID 495440 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([F:14])[C:8]=2[O:12]C)[N:3]=1>Br>[F:14][C:7]1[C:8]([OH:12])=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([CH3:1])[CH:11]=[CH:10]2

참가 물질

3

반응물 1

HCID 22326644HCID 22326644, 화합물

생성물 1

HCID 1355530195-Quinolinol, 6-fluoro-2-methyl-수율 73%

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

A mixture of 2-methyl-5-methoxy-6-fluoroquinoline (2.07 g, 10.8 mmol) and 48% hydrobromic acid (30 ml) was stirred at reflux for 24 h. The reaction mix was reduced to minimum volume in vacuo and partitioned between dichloromethane (50 ml) and sat. aqueous sodium bicarbonate solution (50 ml). The organic layer was dried over sodium sulfate, filtered and evaporated in vacuo to give the title compound as a brown solid (1.39 g, 73%).

후처리

  1. temperatureat reflux for 24 h
  2. additionThe reaction mix
  3. custompartitioned between dichloromethane (50 ml) and sat. aqueous sodium bicarbonate solution (50 ml)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-cc1d97f25d5041eab976e0344acd29d2
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939871B2

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