Dimethyl Sulfoxide → N2-(3-Ethynylphenyl)-N4-(3-quinolinyl)-2,4-pyrimidinediamine

HRID 495453노트

반응식

HRID 495453 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[N:11][C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:5]=[CH:4][N:3]=1.[C:19]([C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=1)[NH2:24])#[CH:20].CS(C)=O>C(Cl)Cl>[C:19]([C:21]1[CH:22]=[C:23]([NH:24][C:2]2[N:7]=[C:6]([NH:8][C:9]3[CH:10]=[N:11][C:12]4[C:17]([CH:18]=3)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:5]=[CH:4][N:3]=2)[CH:25]=[CH:26][CH:27]=1)#[CH:20]

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 104682Benzenamine, 3-ethynyl-HCID 22326846(2-Chloropyrimidin-4-yl)quinolin-3-ylamine

생성물 1

HCID 9945755N2-(3-Ethynylphenyl)-N4-(3-quinolinyl)-2,4-pyrimidinediamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
100 °C

실험 절차

A mixture of (2-chloro-pyrimidin-4-yl)-quinolin-3-yl-amine (70 mg 0.272 mmol) and 3-ethynylaniline (33 mg, 0.282 mmol) was suspended in a sealed tube with 0.3 mL of DMSO. The resulting mixture was heated at 100° C. for 2 h, cooled to RT, diluted with CH2Cl2. The precipitate was collected by suction filtration then dried under vacuum to give the desired product as an off-white solid. M+H—338; Calc'd for C21H15N5: 337.13.

후처리

  1. temperaturecooled to RT
  2. filtrationThe precipitate was collected by suction filtration
  3. customthen dried under vacuum

출처 및 근거

ORD 기록
ord-f0d37dfdfb1c4a55877dfa267a219b3a
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939874B2

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