Hydrogen Bromide → 6-Hydroxy-3-aminoquinoline di-hydrobromide

반응식

C(OC([N:8]1[C:17]2[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=2)[CH:11]=[C:10]([NH2:20])[CH2:9]1)=O)(C)(C)C.[BrH:21]>>[BrH:21].[BrH:21].[OH:18][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][CH:15]=1)[N:8]=[CH:9][C:10]([NH2:20])=[CH:11]2

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 22326880N-tert-butyloxycarbonyl-6-methoxy-3-aminoquinoline

생성물 1

HCID 223268146-Hydroxy-3-aminoquinoline di-hydrobromide

반응 조건

온도: 0 °C

실험 절차

A stirred suspension of N-tert-butyloxycarbonyl-6-methoxy-3-aminoquinoline (Example 134, Step F) (0.274 g, 1 mmol) in HBr (48%, 2.5 mL) was heated at reflux for 48 h. The reaction was cooled to 0° C., and the yellow crystalline solid was filtered off and washed with a small amount of ice-cold water followed by acetone. The yellow crystalline solid was dried over P2O5 to give 6-hydroxy-3-aminoquinoline di-hydrobromide.

후처리

temperaturewas heated
temperatureat reflux for 48 h
filtrationthe yellow crystalline solid was filtered off
washwashed with a small amount of ice-cold water
dry with materialThe yellow crystalline solid was dried over P2O5

출처 및 근거

ORD 기록: ord-cc5f1e8a933e4fe790c1f7d7e7729453
출처 데이터셋: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06939874B2

반응 노트

불러오는 중…