Hydrochloric Acid → 3-Bromophenyl isocyanate

HRID 49550

반응식

HRID 49550 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl.[C:10](OCC)(=[O:12])C>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([N:5]=[C:10]=[O:12])[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 115623-Bromoaniline

생성물 1

HCID 1410013-Bromophenyl isocyanate수율 87%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

3-Bromoaniline (2.63 g, 15.3 mmol) was dissolved in ethyl acetate (100 ml) and 1N dry hydrogen chloride in diethyl ether (15.3 ml) was added and the solvents were removed in vacuo. The residue was stripped twice with toluene and the residue was suspended in toluene (30 ml). Diphosgene (6.1 ml) was added and the mixture was refluxed for 1.5 hour. After cooling, the solution was concentrated in vacuo to afford 2.63 g (87%) 3-bromophenyliso-cyanate.

후처리

  1. customthe solvents were removed in vacuo
  2. additionDiphosgene (6.1 ml) was added
  3. temperaturethe mixture was refluxed for 1.5 hour
  4. temperatureAfter cooling
  5. concentrationthe solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-6e7461da49db41cc9a495add858cf3e5
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706744B2

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