Diethyl Ether → N-(cis)-{2-[(aminoacetyl)amino]cyclohexyl}-4-(aminosulfonyl)benzamide hydrogen bromide
반응식
[NH2:1][S:2]([C:5]1[CH:34]=[CH:33][C:8]([C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[NH:18][C:19](=[O:32])[CH2:20][NH:21]C(=O)OCC2C=CC=CC=2)=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].CCOCC.[BrH:40].CC(O)=O>>[BrH:40].[NH2:21][CH2:20][C:19]([NH:18][C@H:13]1[CH2:14][CH2:15][CH2:16][CH2:17][C@H:12]1[NH:11][C:9](=[O:10])[C:8]1[CH:7]=[CH:6][C:5]([S:2]([NH2:1])(=[O:4])=[O:3])=[CH:34][CH:33]=1)=[O:32]참가 물질
4
실험 절차
The material from above benzyl (cis)-2-[(2-{[4-(aminosulfonyl)benzoyl]amino}cyclohexyl)amino]-2-oxoethylcarbamate (217 mg) was dissolved in 30% HBr/AcOH (5 mL) at rt. After 1 h, Et2O was added and the solid was collected to give N-(cis)-{2-[(aminoacetyl)amino]cyclohexyl}-4-(aminosulfonyl)benzamide hydrogen bromide. MS found: (M+H)+=355.2.