Hydrochloric Acid → Ethyl 2-chlorophenylcarbamate

HRID 495611

반응식

HRID 495611 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10](=[O:11])[O:12][CH2:13][CH3:14]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 72402-ChloroanilineHCID 10928Ethyl chloroformate

생성물 1

HCID 528085Ethyl 2-chlorophenylcarbamate수율 98%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-Chloroaniline (1.4463 g) was dissolved in pyridine (10 ml), and to the solution was added dropwise ethyl chloroformate (1.30 ml) under ice-cooling. After the mixture was stirred for 1 hour, 1N hydrochloric acid was added and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, and then saturated brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (2.2203 g, 98%).

후처리

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with 1N hydrochloric acid
  4. dry with materialsaturated brine, dried over anhydrous magnesium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-20e2a6910ef245dda1b9bea78eba1ec0
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939887B2

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