Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 2-chlorophenyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495613

반응식

HRID 495613 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([C:14]1[C:19]([C:20]([F:23])([F:22])[F:21])=[CH:18][C:17]([N+:24]([O-])=O)=[CH:16][C:15]=1[N+:27]([O-])=O)[C:9](=[O:13])[O:10][CH2:11][CH3:12]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([C:14]1[C:19]([C:20]([F:21])([F:23])[F:22])=[CH:18][C:17]([NH2:24])=[CH:16][C:15]=1[NH2:27])[C:9](=[O:13])[O:10][CH2:11][CH3:12]

참가 물질

4

반응물 1

HCID 20827737Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

생성물 1

HCID 20827736Ethyl 2-chlorophenyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

Ethyl 2-chlorophenyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (0.645 g) was dissolved in ethyl acetate (100 ml), and to the solution was added 10% Pd—C (0.58 g). The reaction mixture was stirred under hydrogen atmosphere for 11 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate and washing were combined and concentrated in vacuo to give the title compound (0.543 g, 98%).

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. washThe filtrate and washing
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-55614f05576d45bc80a182b2496dd400
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939887B2

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