Ethyl 2-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 2-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495619

반응식

HRID 495619 반응식
[Cl:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]([C:11]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][C:14]([N+:21]([O-])=O)=[CH:13][C:12]=1[N+:24]([O-])=O)[C:6](=[O:10])[O:7][CH2:8][CH3:9]>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]([C:11]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][C:14]([NH2:21])=[CH:13][C:12]=1[NH2:24])[C:6](=[O:10])[O:7][CH2:8][CH3:9]

참가 물질

4

반응물 1

HCID 20827734Ethyl 2-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

생성물 1

HCID 20827733Ethyl 2-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate수율 95.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

Ethyl 2-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (103.8 mg) was dissolved in ethyl acetate (20 ml), and to the solution was added 10% Pd—C (105.3 mg). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound (85.6 mg).

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-42b2cb5cb8b84dfab453a2c3b421b67a
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939887B2

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