Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495627

반응식

HRID 495627 반응식
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][C:16]([N+:23]([O-])=O)=[CH:15][C:14]=2[N+:26]([O-])=O)[C:8](=[O:12])[O:9][CH2:10][CH3:11])=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:20])[F:21])=[CH:17][C:16]([NH2:23])=[CH:15][C:14]=2[NH2:26])[C:8](=[O:12])[O:9][CH2:10][CH3:11])=[CH:29][CH:30]=1

참가 물질

4

반응물 1

HCID 20827746Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

생성물 1

HCID 20827745Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate수율 97.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (294.7 mg) was dissolved in ethyl acetate (20 ml), and to the solution was added 10% Pd—C (267.7 mg). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound (248.7 mg).

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-22e9506486f448879edec20695904024
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939887B2

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