Hydrochloric Acid → Ethyl (3-chlorophenyl)carbamate
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH:6]=[CH:7][CH:8]=1참가 물질
5
실험 절차
3-Chloroaniline (2.510 g) was dissolved in pyridine (20 ml), and to the solution was added dropwise ethyl chloroformate (2.257 ml) under ice-cooling. After the mixture was stirred for 1 hour, 1N hydrochloric acid was added and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, and then saturated brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (3.9287 g, quantitative yield).
후처리
- temperaturecooling
- extractionthe mixture was extracted with ethyl acetate
- washThe organic layer was washed with 1N hydrochloric acid
- dry with materialsaturated brine, dried over anhydrous magnesium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-692c75bd73dd43c4b0495b1a0b0416bd
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06939887B2
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