Styrene → 1-Heptene

HRID 495681

반응식

HRID 495681 반응식
[CH2:1]=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C1COCC1>[CH2:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH:2]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)=[CH2:1]

참가 물질

4

반응물 1

HCID 7501Styrene

생성물 2

HCID 116101-HepteneHCID 12757Vinylcyclohexane

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The catalysts of the invention are effective and practical chiral catalysts for enantioselective metathesis. Examples of AROM/CM reactions catalyzed by chiral catalysts of the invention are shown in Table 1. As shown in Example 1, treatment of 19 with 5 equivalents of styrene in the presence of 10 mol % catalyst 9 in THF (50° C.) leads to the formation of 20a in 80% ee and 71% isolated yield (>98% trans). Ru-catalyzed AROM/CM is highly selective with aliphatic olefins. With aliphatic olefins such as 1-heptene and sterically bulky vinylcyclohexane (entries 2-3), 20b-c are obtained in >98% ee, >98% trans and 57-60% yield.

후처리

  1. customisolated
  2. customyield (>98% trans)

출처 및 근거

ORD 기록
ord-7f06d68ce0af49cea785a59f32070a09
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939982B2

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