Water → HCID 18394418, 화합물

HRID 495857노트

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HRID 495857 반응식
[NH2:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4].[C:12](OC(=O)C)(=[O:14])C.O>C(O)=O>[CH:12]([NH:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 7111750D-2-Thienylalanine

생성물 1

HCID 18394418HCID 18394418, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

반응 조건

온도
0 °C

실험 절차

(2R)-2-Amino-3-(2-thienyl)propionic acid (5.00 g, 29.2 mmol) was dissolved in formic acid (50 ml). The solution was cooled to 0° C. Acetic acid anhydride (20 ml) was added dropwise. The reaction mixture was stirred for 16 h, while it was warming up to room temperature. It was cooled to 0° C. Water (20 ml) was added dropwise. The solution was warmed to room temperature. The solvent was is removed in vacuo. The resiude was suspended in ethyl acetate (20 ml). The precipitation was filtered off, collected, and dried in vacuo, to give 3.60 g of crude (2R)-2-(formylamino)-3-(2-thienyl)propionic acid, which was used for the following step.

후처리

  1. temperaturewas warming up to room temperature
  2. temperatureIt was cooled to 0° C
  3. temperatureThe solution was warmed to room temperature
  4. customThe solvent was is removed in vacuo
  5. customThe precipitation
  6. filtrationwas filtered off
  7. customcollected
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-734f22a6f6a947f5acf6e92c5af9e985
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939880B2

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