Ethyl diazoacetate → Ethyl 2-(benzyloxymethyl)cyclopropanecarboxylate

HRID 496051

반응식

HRID 496051 반응식
[N+](=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])=[N-].[CH2:9]([O:16][CH2:17][CH:18]=[CH2:19])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CCOCC>[CH2:9]([O:16][CH2:17][CH:18]1[CH2:19][CH:3]1[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 12192Ethyl diazoacetate2회HCID 84542Allyl benzyl ether

생성물 1

HCID 22325150Ethyl 2-(benzyloxymethyl)cyclopropanecarboxylate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

31.2 g of ethyl diazoacetate are added to a solution of 0.3 mol of allyl benzyl ether in 150 ml of ether with the aid of a push-syringe. After stirring for 16 hours, 31.2 g of ethyl diazoacetate are added again. After 24 hours the mixture is filtered. The organic phase is washed with saturated NaHCO3 solution and then treated in customary manner. Chromatography over silica gel (dichloromethane) allows the expected product to be obtained.

후처리

  1. filtrationAfter 24 hours the mixture is filtered
  2. washThe organic phase is washed with saturated NaHCO3 solution
  3. additiontreated in customary manner
  4. customto be obtained

출처 및 근거

ORD 기록
ord-c809cba580fc45cd9cee4bfaa41681aa
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06943184B2

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