Tetrahydrofuran → (1-(Pyrrolidin-1-yl)cyclopropyl)methanol

HRID 496069노트

반응식

HRID 496069 반응식
[N:1]1([C:6]2([C:9](OCC)=[O:10])[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[N:1]1([C:6]2([CH2:9][OH:10])[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 8028Tetrahydrofuran2회HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 22325082HCID 22325082, 화합물

생성물 1

HCID 22325087(1-(Pyrrolidin-1-yl)cyclopropyl)methanol

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

20.5 g of the product obtained in Step 3 and 100 ml of tetrahydrofuran are poured, over 5 minutes, into a suspension containing 8.57 g of lithium aluminium hydride and 400 ml of tetrahydrofuran. The mixture is heated at reflux for 2 hours, cooled to 5° C. and hydrolysed by successive additions of 9 ml of water, 9 ml of 4N sodium hydroxide solution and then 27 ml of water. The aluminium compound is filtered off and rinsed with tetrahydroflran. The combined filtrates are concentrated to dryness, allowing the desired product to be obtained (liquid).

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 2 hours
  3. filtrationThe aluminium compound is filtered off
  4. washrinsed with tetrahydroflran
  5. concentrationThe combined filtrates are concentrated to dryness
  6. customto be obtained (liquid)

출처 및 근거

ORD 기록
ord-9fa619de0f9a40589588bee84f4458b7
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06943184B2

반응 노트

불러오는 중…