Hydrochloric Acid → 2-Methyl-4-(S)-Phenyl-(L)-Proline Methyl Ester
반응식
C([N:8]1[CH2:16][C@H:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:14][C@@:9]1([CH3:23])[C:10]([O:12][CH3:13])=[O:11])(OC(C)(C)C)=O.Cl>CO>[CH3:13][O:12][C:10](=[O:11])[C@:9]1([CH3:23])[CH2:14][C@@H:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:16][NH:8]1참가 물질
4
실험 절차
To a solution of N-BOC-2-methyl-4-(S)-phenyl-(L)-proline, methyl ester from Step B (1.85 g, 5.8 mmol) in MeOH was bubbled HCl (g) over a 10 min period. The HCl saturated solution was allowed to stir at rt for 5 h, concentrated in vacuo and azeotroped with toluene. The crude product was used in the subsequent step.
후처리
- concentrationconcentrated in vacuo
- customazeotroped with toluene
출처 및 근거
- ORD 기록
- ord-94ef31ecafe043e88be4cefc01edbc9a
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06943180B2
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