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Hydrochloric Acid → 4-(2,3,4,5-tetramethoxy-6-methylbenzyl)benzoic Acid

HRID 496353
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HRID 496353 반응식
[CH3:1][O:2][C:3]1[C:4](=[O:23])[C:5]([CH3:22])=[C:6]([CH2:12][C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[C:7](=O)[C:8]=1[O:9][CH3:10].[C:24](=O)([O-])[O-].[K+].[K+].Cl.[CH3:31][OH:32]>O>[CH3:31][O:32][C:7]1[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[C:4]([O:23][CH3:24])=[C:5]([CH3:22])[C:6]=1[CH2:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=1
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참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 99488164-(5,6-Dimethoxy-3-methyl-1,4-benzoquinon-2-ylmethyl)benzoic acid

생성물 1

HCID 223252774-(2,3,4,5-tetramethoxy-6-methylbenzyl)benzoic Acid수율 76%

시약·촉매·용매 1

HCID 962
Water
용매

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온도
70 °C

실험 절차

The compound (160 mg, 0.45 mmol) obtained in Step 3 was dissolved in a mixture of an aqueous solution of potassium carbonate (91 mg, 0.66 mmol) in water (1 ml) and methanol (2 ml) and the mixture was stirred at 70° C. for 3 hours. The reaction mixture was acidified by adding concentrated hydrochloric acid and then was extracted with diethylether. The extract was washed with water, dried, and then the solvent was distilled off to yield the title compound (116 mg, 0.34 mmol, yield 76%).

후처리

  1. extractionwas extracted with diethylether
  2. washThe extract was washed with water
  3. customdried
  4. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-4366638753ae478e9d958dd2bfa05daa
출처 데이터셋
uspto-grants-2005_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06943196B1

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