Hydroxyamine hydrochloride → 2,4-Dichloro-3-cyano-5-fluorobenzoic acid

HRID 49644노트

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HRID 49644 반응식
Cl.[NH2:2]O.[Cl:4][C:5]1[C:13]([CH:14]=O)=[C:12]([Cl:16])[C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]>C(O)=O>[C:14]([C:13]1[C:5]([Cl:4])=[C:6]([CH:10]=[C:11]([F:17])[C:12]=1[Cl:16])[C:7]([OH:9])=[O:8])#[N:2]

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 186187622,4-Dichloro-5-fluoro-3-formylbenzoic acid

생성물 1

HCID 109005412,4-Dichloro-3-cyano-5-fluorobenzoic acid

시약·촉매·용매 1

HCID 284Formic Acid용매

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온도
102.5 °C

실험 절차

162 g of hydroxylamine hydrochloride were introduced into 2000 ml of formic acid (technical-grade, 85% strength). At 95° C., 950 g of 2,4-dichloro-5-fluoro-3-formylbenzoic acid (moistened with sulphuric acid, 42% strength) were introduced. As a result, the mixture foamed briefly and then a clear solution was immediately obtained. The mixture was then stirred for 4 hours at from 100 to 105° C. (reflux).

후처리

  1. customa clear solution was immediately obtained

출처 및 근거

ORD 기록
ord-e69418f8ce2b4dc2bc8a835e0127e63d
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706918B2

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