3-Cyclohexyl-2-dimethoxymethylacrylonitrile → 2-Cyano-3-cyclohexylpropenal

HRID 496822노트

반응식

HRID 496822 반응식
C[O:2][CH:3](OC)[C:4](=[CH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[C:5]#[N:6]>Cl>[C:5]([C:4](=[CH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH:3]=[O:2])#[N:6]

참가 물질

3

반응물 1

HCID 543234033-Cyclohexyl-2-dimethoxymethylacrylonitrile

생성물 1

HCID 571816332-Cyano-3-cyclohexylpropenal수율 76%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2-(Dimethoxymethyl)-3-cyclohexylacrylonitrile, obtained from Example 3 (4.18 g, 0.02 mol) and 6N HCl (50 mL) were stirred together overnight at room temperature. The product was extracted with ethyl acetate (200 mL), the extract was dried) (MgSO4) and the ethyl acetate was evaporated in vacuo to give a 2.5 g (76%) of a brown oil which was used directly. A sample was distilled in a kugelrohr apparatus to give a pale yellow oil from which an analytical 2,4-dinitrophenyl hydrazone derivative was obtained as orange needles, mp 228-30° C.

후처리

  1. extractionThe product was extracted with ethyl acetate (200 mL)
  2. dry with materialthe extract was dried) (MgSO4)
  3. customthe ethyl acetate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-4453313c10f14955a4e9e33705d4043f
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06946554B2

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