Ethanol → Ethyl 2-(3-hydroxy-4-nitrophenyl)acetate
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH2:15](O)[CH3:16]>Cl>[OH:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]참가 물질
4
실험 절차
A solution of 3-hydroxy-4-nitrophenylacetic acid (4.0 g, prepared according to the procedure described by Meyer et al, J.Med.Chem., 1997, 40, pages 1049-1062) in ethanol (approximately 100 mL) was treated with concentrated hydrochloric acid (5-8 drops) was heated at reflux temperature for 3 hours then evaporated. The residue was dissolved in tert-butyl methylether and the solution was washed with saturated aqueous sodium bicarbonate solution, then with water, then dried, and then evaporated to give the title compound (5.0 g) as a light yellow solid.
후처리
- temperaturewas heated
- temperatureat reflux temperature for 3 hours
- customthen evaporated
- dissolutionThe residue was dissolved in tert-butyl methylether
- washthe solution was washed with saturated aqueous sodium bicarbonate solution
- dry with materialwith water, then dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-d308b8da7bb94c82a8950bd040312d69
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06706738B2
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