N-Hydroxypropionimidamide → HCID 22318613, 화합물

HRID 497048

반응식

HRID 497048 반응식
[Cl:1][C:2]1[C:3]([O:18][CH2:19][CH2:20][CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=2)=[C:4]([CH:9]=[C:10]([O:12][CH2:13][CH:14]=[C:15]([Cl:17])[Cl:16])[CH:11]=1)[C:5](OC)=[O:6].[C:33](=[N:37]O)([NH2:36])[CH2:34][CH3:35].[Na]>C(O)C>[Cl:1][C:2]1[CH:11]=[C:10]([O:12][CH2:13][CH:14]=[C:15]([Cl:17])[Cl:16])[CH:9]=[C:4]([C:5]2[O:6][N:37]=[C:33]([CH2:34][CH3:35])[N:36]=2)[C:3]=1[O:18][CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:30])([F:31])[F:32])=[CH:25][N:24]=1

참가 물질

5

반응물 3

HCID 4092053N-HydroxypropionimidamideHCID 5360545SodiumHCID 22318619HCID 22318619, 화합물

생성물 1

HCID 22318613HCID 22318613, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
40 °C

실험 절차

0.05 g of methyl 3-chloro-5-(3,3-dichloroprop-2-enyloxy)-2-[3-(5-trifluoromethylpyrid-2-yloxy)propyloxy]benzoate and 0.028 g of propionamidoxime were dissolved in 1 ml of anhydrous ethanol. A solution of 0.008 g of sodium in 0.5 ml of ethanol was added to this solution. The mixture was stirred at 40° C. for 2 hours and at room temperature for 20 hours. The mixture was then concentrated, and diethyl ether and water were added. After shaking, the ether phase was isolated, dried and concentrated under reduced pressure, and the crude product was purified chromatographically. Yield: 0.017 g (32%)

후처리

  1. concentrationThe mixture was then concentrated
  2. additiondiethyl ether and water were added
  3. stirringAfter shaking
  4. customthe ether phase was isolated
  5. customdried
  6. concentrationconcentrated under reduced pressure
  7. customthe crude product was purified chromatographically

출처 및 근거

ORD 기록
ord-68ae83fbb67c491bb414b7c859e79a24
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949551B2

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