Water → 2-Acetamido-5-bromopyridine

HRID 49719

반응식

HRID 49719 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1.O>C(O)(=O)C>[Br:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:5](=[O:7])[CH3:6])=[N:10][CH:11]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 706222-Amino-5-bromopyridine

생성물 1

HCID 2930972-Acetamido-5-bromopyridine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Acetic anhydride (27.4 mL) was added to a stirred suspension of 2-amino-5-bromopyridine (10.0 g) in acetic acid (40 mL). The mixture was heated at reflux for 4 hours, then cooled to room temperature and then poured into water (200 mL). The resulting solid was collected, washed three times with water (300 ml) and then dried in vacuo at 70° C., affording the title compound as a white solid (10.9 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe resulting solid was collected
  4. washwashed three times with water (300 ml)
  5. customdried in vacuo at 70° C.

출처 및 근거

ORD 기록
ord-a8376e32560e4ae2b4a581d3d9db980c
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706738B2

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