1,4-Diacetylbenzene → 1-(4-Acetylphenyl)-2-bromo-1-ethanone

HRID 497213

반응식

HRID 497213 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:13]Br>C(OCC)C.O.[Cl-].[Al+3].[Cl-].[Cl-]>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH2:2][Br:13])=[CH:5][CH:6]=1)(=[O:12])[CH3:11]

참가 물질

6

반응물 2

HCID 138881,4-DiacetylbenzeneHCID 24408Bromine

생성물 1

HCID 149132991-(4-Acetylphenyl)-2-bromo-1-ethanone수율 88.8%

시약·촉매·용매 3

HCID 6451240Aluminum(III) Chloride촉매HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

To a stirred solution of 1,4-diacetylbenzene (5.3 g, 32.7 mmol), aluminum chloride (0.05 g, 0.38 mmol) in diethylether (50 ml) was added bromine (5.3 g, 32.7 mmol) dropwise over 20 minutes. The mixture was stirred for 30 minutes, and diluted with water. The whole was concentrated to remove diethylether, and the aqueous suspension was filtered to give 7.0 g of white solid. The compound was used for next reaction without purification.

후처리

  1. concentrationThe whole was concentrated
  2. customto remove diethylether
  3. filtrationthe aqueous suspension was filtered

출처 및 근거

ORD 기록
ord-51c10d8c02a449f0b3274ef84328c10f
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949536B2

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