Water → HCID 86759852, 화합물

HRID 497726

반응식

HRID 497726 반응식
Cl[C:2]1[C:3]2[S:20][C:19]([NH2:21])=[N:18][C:4]=2[N:5]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=2[F:17])[N:7]=1.[NH2:22][CH2:23][C@H:24](O)[CH3:25].[OH2:27]>CN1CCCC1=O.CCN(C(C)C)C(C)C>[NH2:21][C:19]1[S:20][C:3]2[C:2]([NH:22][CH:23]([OH:27])[CH2:24][CH3:25])=[N:7][C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=3[F:17])=[N:5][C:4]=2[N:18]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 439938(2R)-1-aminopropan-2-olHCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

생성물 1

HCID 86759852HCID 86759852, 화합물

시약·촉매·용매 2

HCID 13387N-methyl-2-pyrrolidone용매HCID 81531Diisopropylethylamine용매

실험 절차

The product from example 1, step (b) (70.0 g) and (R)-1-amino-propan-2-ol (32 ml) in N-methylpyrrolidinone (600 ml) and Hunigs base (71 ml) was heated at 110° C. for 16 hours. The mixture was poured into water (5 L) and the crude product collected at by filtration. This solid was purified by recrystallisation from acetonitrile (2.5 L) to give 65 g of the subtitled compound.

후처리

  1. filtrationthe crude product collected at by filtration
  2. customThis solid was purified by recrystallisation from acetonitrile (2.5 L)

출처 및 근거

ORD 기록
ord-1c6fd978249740a2a653eae94ca91aa6
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949643B2

연결된 노트

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