Diethyl (ethoxymethylene)malonate → Diethyl 2-([[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]methylene)malonate

HRID 497934

반응식

HRID 497934 반응식
C(O[CH:4]=[C:5]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[CH3:16][C:17]1[CH:21]=[C:20]([NH2:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[N:18]=1>>[CH3:16][C:17]1[CH:21]=[C:20]([NH:22][CH:4]=[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[N:18]=1

참가 물질

3

반응물 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 7351323-Methyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine

생성물 1

HCID 22320362Diethyl 2-([[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]methylene)malonate수율 96%

반응 조건

온도
120 °C

실험 절차

A mixture of diethyl ethoxymethylenemalonate (32.5 g, 0.15 mol) and 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-amine (23.8 g, 0.137 mol) was heated under reflux at 120° C. for 1 hour. After the mixture was allowed to cool to room temperature, the reaction solvent was evaporated under reduced pressure. The crude crystals thus obtained were filtered and washed with diethylether to give the title compound (45 g, 96% yield).

후처리

  1. temperaturewas heated
  2. temperatureto cool to room temperature
  3. customthe reaction solvent was evaporated under reduced pressure
  4. customThe crude crystals thus obtained
  5. filtrationwere filtered
  6. washwashed with diethylether

출처 및 근거

ORD 기록
ord-34b8fc18d8c74f8bba3d7ab89fdd719a
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

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