Ethyl Acetate → HCID 178429193, 화합물

HRID 497957

반응식

HRID 497957 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([NH2:7])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:3]=1.[C:14](OCC)(=[O:19])[CH2:15][C:16]([CH3:18])=O.C(OCC)(=O)C>C(O)(=O)C>[CH3:1][C:2]1[C:6]2[C:5](=[N:7][C:14]([OH:19])=[CH:15][C:16]=2[CH3:18])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 8868Ethyl AcetoacetateHCID 7351323-Methyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine

생성물 1

HCID 178429193HCID 178429193, 화합물수율 63.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-amine (5.1 g, 29 mmol) and ethyl acetoacetate (3.8 g, 30 mmol) in acetic acid (14 mL) was stirred at 100° C. for 4 hours. The solution was cooled to room temperature and ethyl acetate was added thereto. The resulting crude crystals were collected by filtration, and recrystallized from ethanol to give the title compound (4.4 g, 62% yield).

후처리

  1. filtrationThe resulting crude crystals were collected by filtration
  2. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-7f85c5375b614450a81179d53aaa42b7
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

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