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1-Butanol → (R)-1-(1-Phenylethylamino)-4-(4-pyridylmethyl)phthalazine dihydrochloride

HRID 49864
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HRID 49864 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:4][N:3]=1.[C:19]1([C@@H:25]([NH2:27])[CH3:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(O)CCC>O>[ClH:1].[ClH:1].[C:19]1([C@H:25]([NH:27][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([CH2:12][C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[N:4][N:3]=2)[CH3:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 2631-ButanolHCID 758181-Phenethylamine, (-)-HCID 19446091-Chloro-4-(4-pyridinylmethyl)phthalazine

생성물 1

HCID 69837621(R)-1-(1-Phenylethylamino)-4-(4-pyridylmethyl)phthalazine dihydrochloride

시약·촉매·용매 1

HCID 962Water용매

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온도
110 °C

실험 절차

A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine, 1.273 ml (10 mmol) (S)-1 phenylethylamine and 5 ml 1-butanol is stirred for 40 h at 110° C. After processing as described in Example 12 and equilibration for 65 hours at 20° C. and in room atmosphere, title compound is obtained with a water content of 10.53%; m.p. 190° C. (decomp.); ESI-MS: (M+H)+=341; [α]D20=+38.4±0.70 (c=1.507%, methanol).

후처리

  1. waitas described in Example 12 and equilibration for 65 hours at 20° C. and in room atmosphere

출처 및 근거

ORD 기록
ord-0e3f3997fada4ff0972d23f85223536c
출처 데이터셋
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06710047B2

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